Urinary Estrogens and Metabolites

Estrogen deficiencies give rise to many symptoms such as hot flushes, vaginal atrophy and memory loss. This test can diagnose an estrogen deficiency as well as monitor bioidentical estrogen supplementation. Urinary hormone testing has the advantage over blood tests that it assays only the biologically active hormones and therefore correlates better with symptoms. 2 hydroxy estrone (2OHE1) is a powerful antioxidant and its presence is beneficial. The 16α hydroxy estrone (16αOHE1) metabolite is considered the more harmful tissue proliferative OHE1 and has been shown when not controlled to represent a health risk. A decreased 2/16αOHE1 ratio is a marker of breast cancer risk, with a ratio greater than 2 being most desirable, whereas an increased 2/16αOHE1 ratio coupled with low estradiol is associated with osteoporosis risk. The 4 hydroxy estrone (4OHE1) metabolite is a powerful free radical generator and has also been shown to correlate with an increased risk for breast cancer.

Urine Test for Estrone (E1), Estradiol (E2), Estriol (E3), 2OH Estrone, 4OH Estrone, 16αOH Estrone
First morning void or 24 hour urine collection