Estrogen Metabolism Index 3

2 hydroxy estrone (2OHE1) is a powerful antioxidant and its presence is beneficial. The 16α hydroxy estrone (16αOHE1) metabolite is considered the more harmful tissue proliferative OHE1 and has been shown when not controlled to represent a health risk. A decreased 2/16αOHE1 ratio is a marker of breast cancer risk, with a ratio greater than 2 being most desirable, whereas an increased 2/16αOHE1 ratio coupled with low estradiol is associated with
osteoporosis risk. The 4 hydroxy estrone (4OHE1) metabolite is a powerful free radical generator and has also been shown to correlate with an increased risk for breast cancer. The methoxy estrone’s (2MeOE1 and 4MeOE1) are produced from the methylation of the 2OHE1 and 4OHE1. The level of 2 methoxy estrone (2MeOE1) has been correlated with breast cancer, with a lower level being present in breast cancer tissue. This estrogen metabolite is known to
have anti-proliferative, anti-angiogenic and apoptotic properties.

Urine Test for 2OH Estrone, 4OH Estrone, 16αOH Estrone, 2MeO Estrone, 4MeO Estrone and 2/16αOH Estrone Ratio
24 hour urine collection